Modeling of Biological Processes using Subthreshold Analog Circuits

The ability to reliably and quickly model the behavior of basic biological processes may allow future analysis of complex biological systems and the use of models for drug research and development.

As equations describing transistor operation below the threshold voltage and equations describing chemical reactions have significant similarities, analog circuits can be designed to model biochemical reactions and biological processes.

In cytomorphic engineering the cellular behavior of biological systems is modeled using analog circuits. For example, the process of making a protein according to a genetic code found in DNA can be modeled using an analog circuit that includes differential amplifiers, current mirrors and capacitive loads as shown in the diagram.

Project Goal

The project will focus on the design of analog circuits for the purpose of modeling a specific biological process.

In this project the student will experience the design of trans-linear analog circuits operating under the voltage and will be exposed to the biological processes to be modeled. The design of the circuit will be performed in the Tower 0.18um technology using the Cadence Virtuoso tools and will include the implementation of the circuit from the transistor level to the layout level.

Supervisor : Ilan Oren